Letter: Candida albicans and polyene antibiotics.
نویسندگان
چکیده
منابع مشابه
Development of Resistance to Polyene Antibiotics in Candida Albicans.
Hebeka, Elias K. (Rutgers, The State University, New Brunswick, N.J.), and Morris Solotorovsky. Development of resistance to polyene antibiotics in Candida albicans. J. Bacteriol. 89:1533-1539. 1965.-Strains of Candida albicans resistant to the polyenes candidin and amphotericin B, but not to nystatin, were developed by sub-culturing the organism in gradually increasing concentrations of the an...
متن کاملDissociation between ion permeability and the lethal action of polyene antibiotics on Candida albicans.
Kinetic data on potassium release from and killing of Candida albicans by the four polyene antibiotics amphotericin B, amphotericin B methyl ester hydrochloride, nystatin, and nystatin methyl ester hydrochloride are presented. The nystatins were relatively more effective than the amphotericins in causing potassium release rather than killing. These data suggest that the aqueous channels or pore...
متن کاملThe release of potassium ions from Candida albicans in the presence of polyene antibiotics.
The addition of amphotericin methyl ester (AME) to suspensions of Candida albicans is followed by a progressively increasing rate of release of Kf from within the cell. The time taken for a given rate of release to be reached depends upon the AME concentration (the product of AME concentration and time being approximately constant), the pH and concentration of buffer, the temperature, the suspe...
متن کاملPolyene Antifungal Antibiotics
ZYGMUNT, WALTER A. (Mead Johnson Research Center, Evansville, Ind.). Intracellular loss of potassium in Candida albicans after exposure to polyene antifungal antibiotics. Appl. Microbiol. 14:953-956. 1966.-Eleven antifungal antibiotics, representing three broad macrolide classes, were studied in Candida albicans for their effect on growth and on the fate of intracellular K+. Marked differences ...
متن کاملThe polyene macrolide antibiotics.
The mode of action of the polyene antibiotics is reviewed together with the effect of genetic and environmental factors on sensitive organisms. The future prospects of polyenes in the treatment of systemic mycoses are considered.
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ژورنال
عنوان ژورنال: BMJ
سال: 1976
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.6034.522